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1

Dynamic personalities of proteins

Henzler-Wildman, Katherine, Kern, Dorothee

Journal:

Year:

2007

Language:

english

File:

PDF, 663 KB

english, 2007

2

10.1038/47273

Kern, Dorothee, Volkman, Brian F., Luginbühl, Peter, Nohaile, Michael J., Kustu, Sydney, Wemmer, David E.

Journal:

Language:

english

File:

PDF, 587 KB

english

3

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

Henzler-Wildman, Katherine A., Lei, Ming, Thai, Vu, Kerns, S. Jordan, Karplus, Martin, Kern, Dorothee

Journal:

Year:

2007

Language:

english

File:

PDF, 893 KB

english, 2007

4

Structural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the Mimivirus

Vu Thai, Patricia Renesto, C. Andrew Fowler, Darin J. Brown, Tara Davis, Wanjun Gu, David D. Pollock, Dorothee Kern, Didier Raoult, Elan Z. Eisenmesser

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1001 KB

english, 2008

5

Choreographing an enzyme's dance

Janice Villali, Dorothee Kern

Journal:

Current Opinion in Chemical Biology

Year:

2010

Language:

english

File:

PDF, 467 KB

english, 2010

6

Structural properties of the histidine-containing loop in HIV-1 RNase H

Gunther Kern, Jeff Pelton, Susan Marqusee, Dorothee Kern

Journal:

Biophysical Chemistry

Year:

2002

Language:

english

File:

PDF, 354 KB

english, 2002

7

Kinetics of folding and association of differently glycosylated variants of invertase from saccharomyces cerevisiae

Gunther Kern, Dorothee Kern, Rainer Jaenicke, Robert Seckler

Journal:

Protein Science

Year:

1993

Language:

english

File:

PDF, 740 KB

english, 1993

8

Mesodynamics in the SARS nucleocapsid measured by NMR field cycling

Michael W. Clarkson, Ming Lei, Elan Z. Eisenmesser, Wladimir Labeikovsky, Alfred Redfield, Dorothee Kern

Journal:

Journal of Biomolecular NMR

Year:

2009

Language:

english

File:

PDF, 526 KB

english, 2009

9

In vitro influence of ultrasonic stress, removal force preload and thermocycling on the retrievability of implant-retained crowns

Christian Mehl, Sönke Harder, Dorothee Schwarz, Martin Steiner, Oliver Vollrath, Matthias Kern

Journal:

Clinical Oral Implants Research

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

10

Intrinsic dynamics of an enzyme underlies catalysis

Eisenmesser, Elan Z., Millet, Oscar, Labeikovsky, Wladimir, Korzhnev, Dmitry M., Wolf-Watz, Magnus, Bosco, Daryl A., Skalicky, Jack J., Kay, Lewis E., Kern, Dorothee

Journal:

Year:

2005

Language:

english

File:

PDF, 485 KB

english, 2005

11

Hidden alternative structures of proline isomerase essential for catalysis

Fraser, James S., Clarkson, Michael W., Degnan, Sheena C., Erion, Renske, Kern, Dorothee, Alber, Tom

Journal:

Year:

2009

Language:

english

File:

PDF, 781 KB

english, 2009

12

Cutting the leash

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 624 KB

english, 2002

13

Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

Wolf-Watz, Magnus, Thai, Vu, Henzler-Wildman, Katherine, Hadjipavlou, Georgia, Eisenmesser, Elan Z, Kern, Dorothee

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 623 KB

english, 2004

14

The role of dynamics in allosteric regulation

Dorothee Kern, Erik RP Zuiderweg

Journal:

Current Opinion in Structural Biology

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

15

Activation of thiamin diphosphate in enzymes

Gerhard Hübner, Kai Tittmann, Margrit Killenberg-Jabs, Jörg Schäffner, Michael Spinka, Holger Neef, Dorothee Kern, Gunther Kern, Gunter Schneider, Christer Wikner, Sandro Ghisla

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1998

Language:

english

File:

PDF, 295 KB

english, 1998

16

Structural and functional analyses of activating amino acid substitutions in the receiver domain of NtrC: Evidence for an activating surface

Michael Nohaile, Dorothee Kern, David Wemmer, Kenneth Stedman, Sydney Kustu

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 2.47 MB

english, 1997

17

The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin

Dorothee Kern, Torbjörn Drakenberg, Mats Wikström, Sture Forsén, Holger Bang, Gunter Fischer

Journal:

Year:

1993

Language:

english

File:

PDF, 484 KB

english, 1993

18

Reassessment of the putative chaperone function of prolyl-cis/trans-isomerases

Gunther Kern, Dorothee Kern, Franz X. Schmid, Gunter Fischer

Journal:

Year:

1994

Language:

english

File:

PDF, 546 KB

english, 1994

19

Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein

Alexandra K. Gardino, Janice Villali, Aleksandr Kivenson, Ming Lei, Ce Feng Liu, Phillip Steindel, Elan Z. Eisenmesser, Wladimir Labeikovsky, Magnus Wolf-Watz, Michael W. Clarkson, Dorothee Kern

Journal:

Year:

2009

Language:

english

File:

PDF, 903 KB

english, 2009

20

Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

Fabian Bartz, Luise Kern, Dorothee Erz, Mingang Zhu, Daniel Gilbert, Till Meinhof, Ute Wirkner, Holger Erfle, Martina Muckenthaler, Rainer Pepperkok, Heiko Runz

Journal:

Cell Metabolism

Year:

2009

Language:

english

File:

PDF, 2.41 MB

english, 2009

21

Structure and Dynamics of Pin1 During Catalysis by NMR

Wladimir Labeikovsky, Elan Z. Eisenmesser, Daryl A. Bosco, Dorothee Kern

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.36 MB

english, 2007

22

Segmented Transition Pathway of the Signaling Protein Nitrogen Regulatory Protein C

Ming Lei, Janice Velos, Alexandra Gardino, Alexsandr Kivenson, Martin Karplus, Dorothee Kern

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 813 KB

english, 2009

23

Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR

Daryl A. Bosco, Elan Zohar Eisenmesser, Michael W. Clarkson, Magnus Wolf-Watz, Wladimir Labeikovsky, Oscar Millet, Dorothee Kern

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 2.02 MB

english, 2010

24

Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening

Sangwoo Shim, Joseph P. Yuan, Ju Young Kim, Weizhong Zeng, Guo Huang, Aleksandr Milshteyn, Dorothee Kern, Shmuel Muallem, Guo-li Ming, Paul F. Worley

Journal:

Year:

2009

Language:

english

File:

PDF, 1.55 MB

english, 2009

25

The NMR Solution Structure of BeF3−-Activated Spo0F Reveals the Conformational Switch in a Phosphorelay System

Alexandra K. Gardino, Brian F. Volkman, Ho S. Cho, Seok-Yong Lee, David E. Wemmer, Dorothee Kern

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.62 MB

english, 2003

26

Probing Microsecond Time Scale Dynamics in Proteins by Methyl 1 H Carr−Purcell−Meiboom−Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrC r

Otten, Renee, Villali, Janice, Kern, Dorothee, Mulder, Frans A. A.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 507 KB

english, 2010

27

Energy Landscape of Adenylate Kinase: Phosphoryl Transfer and Conformational Transitions

Agafonov, Roman, Kerns, Jordan, Phung, Lien, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 143 KB

english, 2011

28

[Methods in Enzymology] Nuclear Magnetic Resonance of Biological Macromolecules Volume 394 || Enzyme Dynamics During Catalysis Measured by NMR Spectroscopy

Year:

2005

Language:

english

File:

PDF, 471 KB

english, 2005

29

Evidence Against the “Y–T Coupling” Mechanism of Activation in the Response Regulator NtrC

Villali, Janice, Pontiggia, Francesco, Clarkson, Michael W., Hagan, Michael F., Kern, Dorothee

Journal:

Journal of Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

30

Direct Observation of Conformational Exchange in the Small Multidrug Resistance Transporter EmrE

Morrison, Emma, Dekoster, Greg, Dutta, Supratik, Clarkson, Michael, Vafabakhsh, Reza, Kern, Dorothee, Ha, Taekjip, Henzler-Wildman, Katherine

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 41 KB

english, 2012

31

Cyclophilin Dynamics and Catalysis are Mechanistically Linked

Clarkson, Michael W., Fraser, James, Alber, Thomas, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 118 KB

english, 2009

32

Tau vs. Glycerol - A Kinetic Study of the Tubulin Polymerization

Kutter, Steffen, Deaconescu, Alexandra, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

33

Conformational pathways of Adenylate Kinase characterized by computations, pressure and experiments

Pachov, Dimitar, Kerns, Scott J., Kern, Dorothee

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

34

Erratum

Pachov, Dimitar, Kerns, Scott J., Kern, Dorothee

Journal:

Current Opinion in Cell Biology

Year:

1992

Language:

english

File:

PDF, 57 KB

english, 1992

35

Experimental Confirmation of an NtrC Transition Pathway Predicted by Targeted MD

Velos, Janice, Lei, Ming, Liu, Ce Feng, Steindel, Phillip, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

36

Visualizing Adenylate Kinase Catalysis Through the X-ray Lens

Cho, Young-Jin, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

37

Under New Management

Lei, Ming, Velos, Janice, Gardino, Alexandra, Karplus, Martin, Kern, Dorothee

Journal:

Year:

1948

Language:

english

File:

PDF, 374 KB

english, 1948

38

Segmented Transition Pathway Of The Receiver Domain Of Nitrogen Regulatory Protein C

Lei, Ming, Velos, Janice, Gardino, Alexandra, Karplus, Martin, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 39 KB

english, 2009

39

Probing an Ancient Protein's Dynamics with NMR

Hoemberger, Marc S., Wilson, Christopher G., Kern, Dorothee

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 53 KB

english, 2014

40

Molecular Mechanisms Underlying the Clinical Success of the Cancer Drug Gleevec

Agafonov, Roman V., Wilson, Chris, Otten, Renee, Buosi, Vanessa, Kern, Dorothee

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 39 KB

english, 2014

41

Proteins in Flagrante: Excursions in Silico and in Proteo

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 57 KB

english, 2013

42

Rotational Barriers of cis / trans Isomerization of Proline Analogues and Their Catalysis by Cyclophilin §

Kern, Dorothee, Schutkowski, Mike, Drakenberg, Torbjörn

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 192 KB

english, 1997

43

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases

Agafonov, Roman V, Wilson, Christopher, Otten, Renee, Buosi, Vanessa, Kern, Dorothee

Journal:

Nature Structural and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

44

Kinetic Analysis of Cyclophilin-Catalyzed Prolyl Cis/Trans Isomerization by Dynamic NMR Spectroscopy

Kern, Dorothee, Kern, Gunther, Scherer, Gerd, Fischer, Gunter, Drakenberg, Torbjoern

Journal:

Year:

1995

Language:

english

File:

PDF, 1.07 MB

english, 1995

45

Kinetic Control of Thiamin Diphosphate Activation in Enzymes Studied by Proton−Nitrogen Correlated NMR Spectroscopy †

Tittmann, Kai, Neef, Holger, Golbik, Ralph, Hübner, Gerhard, Kern, Dorothee

Journal:

Year:

2005

Language:

english

File:

PDF, 72 KB

english, 2005

46

Catalysis and Binding of Cyclophilin A with Different HIV-1 Capsid Constructs †

Bosco, Daryl A., Kern, Dorothee

Journal:

Year:

2004

Language:

english

File:

PDF, 313 KB

english, 2004

47

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

Morrison, Emma A., DeKoster, Gregory T., Dutta, Supratik, Vafabakhsh, Reza, Clarkson, Michael W., Bahl, Arjun, Kern, Dorothee, Ha, Taekjip, Henzler-Wildman, Katherine A.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

48

A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy

Hass, Mathias A. S., Liu, Wei-Min, Agafonov, Roman V., Otten, Renee, Phung, Lien A., Schilder, Jesika T., Kern, Dorothee, Ubbink, Marcellus

Journal:

Journal of Biomolecular NMR

Year:

2015

Language:

english

File:

PDF, 2.81 MB

english, 2015

49

Molecular and structural transmembrane determinants critical for embedding claudin-5 into tight junctions reveal a distinct four-helix bundle arrangement

Rossa, Jan, Protze, Jonas, Kern, Christian, Piontek, Anna, Günzel, Dorothee, Krause, Gerd, Piontek, Jörg

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.87 MB

english, 2014

50

Molecular mechanism of Pin1-tau recognition and catalysis

Eichner, Timo, Kutter, Steffen, Labeikovsky, Wladimir, Buosi, Vanessa, Kern, Dorothee

Journal:

Journal of Molecular Biology

Year:

2016

Language:

english

File:

PDF, 2.12 MB

english, 2016